:root {
  --bg: #f7f9fc;
  --bg2: #eef2f9;
  --card: #ffffff;
  --card2: #f4f7fd;
  --line: #e3e9f4;
  --text: #1c2536;
  --muted: #66738c;
  --accent: #0ea5a4;
  --accent2: #2563eb;
  --grad: linear-gradient(135deg, #0ea5a4 0%, #2563eb 100%);
  --gold: #b45309;
  --red: #dc2626;
  --green: #16a34a;
  --orange: #ea580c;
  --shadow: 0 1px 2px rgba(28, 37, 54, .04), 0 8px 24px -12px rgba(28, 37, 54, .12);
  --shadow-lift: 0 2px 4px rgba(28, 37, 54, .05), 0 16px 40px -16px rgba(37, 99, 235, .25);
  --radius: 18px;
}
* { box-sizing: border-box; margin: 0; padding: 0; }
html { scroll-behavior: smooth; }
body {
  background:
    radial-gradient(1200px 500px at 80% -200px, rgba(14, 165, 164, .08), transparent),
    radial-gradient(1000px 500px at 0% -200px, rgba(37, 99, 235, .07), transparent),
    var(--bg);
  color: var(--text);
  font-family: -apple-system, BlinkMacSystemFont, "PingFang SC", "Hiragino Sans GB",
    "Microsoft YaHei", "Segoe UI", sans-serif;
  line-height: 1.75;
  -webkit-font-smoothing: antialiased;
}
.wrap { max-width: 1080px; margin: 0 auto; padding: 0 22px; }
a { color: var(--accent2); text-decoration: none; transition: color .15s ease; }
a:hover { color: var(--accent); }

/* 头部 */
.site-header {
  position: sticky; top: 0; z-index: 50;
  background: rgba(247, 249, 252, .82);
  backdrop-filter: saturate(180%) blur(14px);
  -webkit-backdrop-filter: saturate(180%) blur(14px);
  border-bottom: 1px solid var(--line);
  padding: 14px 0 10px;
}
.brand { display: flex; align-items: center; gap: 14px; }
.logo {
  font-size: 34px; width: 58px; height: 58px; display: grid; place-items: center;
  background: var(--grad); border-radius: 16px;
  box-shadow: 0 8px 20px -8px rgba(37, 99, 235, .5);
}
.brand h1 { font-size: 22px; font-weight: 800; letter-spacing: .2px; }
.brand h1 em {
  font-style: normal; font-size: 13px; font-weight: 600;
  background: var(--grad); -webkit-background-clip: text; background-clip: text; color: transparent;
  display: block; letter-spacing: .6px;
}
.sub { color: var(--muted); font-size: 12.5px; margin-top: 1px; }
.top-nav { display: flex; flex-wrap: wrap; gap: 6px; margin-top: 12px; }
.top-nav a {
  padding: 5px 13px; border-radius: 999px; font-size: 13px; font-weight: 500;
  background: transparent; border: 1px solid transparent; color: var(--muted);
  transition: all .18s ease;
}
.top-nav a:hover { background: var(--card); color: var(--accent2); border-color: var(--line); box-shadow: var(--shadow); text-decoration: none; transform: translateY(-1px); }
.top-nav a.active { background: var(--grad); color: #fff; border-color: transparent; box-shadow: 0 6px 16px -6px rgba(37, 99, 235, .45); }

.disclaimer-bar {
  background: linear-gradient(90deg, #fffbeb, #fef3c7);
  border-bottom: 1px solid #fde68a;
  color: #92400e; font-size: 12.5px; text-align: center; padding: 8px 16px;
}

main { padding: 30px 22px 70px; animation: fadeUp .45s ease both; }
@keyframes fadeUp { from { opacity: 0; transform: translateY(10px); } to { opacity: 1; transform: none; } }
.loading { text-align: center; color: var(--muted); padding: 90px 0; }

h2.sec { font-size: 21px; margin: 38px 0 6px; display: flex; align-items: center; gap: 8px; font-weight: 800; }
h2.sec:first-child { margin-top: 4px; }
.sec-sub { color: var(--muted); font-size: 13.5px; margin-bottom: 16px; }

/* 概览 */
.hero { display: grid; grid-template-columns: repeat(auto-fit, minmax(160px, 1fr)); gap: 14px; margin-top: 6px; }
.stat-card {
  background: var(--card); border: 1px solid var(--line); border-radius: var(--radius);
  padding: 18px 20px; box-shadow: var(--shadow); transition: transform .18s ease, box-shadow .18s ease;
}
.stat-card:hover { transform: translateY(-3px); box-shadow: var(--shadow-lift); }
.stat-card .num {
  font-size: 26px; font-weight: 800;
  background: var(--grad); -webkit-background-clip: text; background-clip: text; color: transparent;
}
.stat-card .lbl { font-size: 12.5px; color: var(--muted); margin-top: 2px; }

.profile-card {
  background: var(--card); border: 1px solid var(--line); border-radius: var(--radius);
  padding: 20px 22px; margin-top: 16px; box-shadow: var(--shadow);
}
.profile-card h3 { font-size: 15px; margin-bottom: 10px; color: var(--accent2); font-weight: 700; }
.profile-card p { font-size: 14px; }
.badge {
  display: inline-block; padding: 3px 12px; border-radius: 999px; font-size: 12.5px; font-weight: 500;
  border: 1px solid var(--line); background: var(--card2); color: var(--muted); margin: 3px 6px 3px 0;
  transition: all .15s ease;
}
.badge:hover { border-color: var(--accent2); color: var(--accent2); }
.badge.hl {
  color: #fff; background: var(--grad); border-color: transparent; font-weight: 600;
  box-shadow: 0 4px 12px -4px rgba(37, 99, 235, .4);
}

/* 科普卡 */
.popsci-card {
  background: linear-gradient(135deg, #f0fdfa, #eff6ff);
  border: 1px solid #ccfbf1; border-radius: var(--radius);
  padding: 16px 20px; margin: 12px 0; font-size: 14px;
}
.popsci-card h4 { font-size: 14.5px; margin-bottom: 4px; color: #0f766e; font-weight: 700; }
.popsci-card p { color: #334155; }

/* 模块卡 */
.module-grid { display: grid; grid-template-columns: repeat(auto-fill, minmax(300px, 1fr)); gap: 16px; margin-top: 16px; }
.module-card {
  display: block; background: var(--card); border: 1px solid var(--line);
  border-radius: var(--radius); padding: 20px 22px; color: var(--text); box-shadow: var(--shadow);
  transition: transform .18s ease, box-shadow .18s ease, border-color .18s ease;
}
.module-card:hover { transform: translateY(-4px); box-shadow: var(--shadow-lift); border-color: #bfdbfe; text-decoration: none; }
.module-card .ic {
  font-size: 24px; width: 46px; height: 46px; display: grid; place-items: center;
  background: var(--card2); border-radius: 13px; margin-bottom: 10px;
}
.module-card h3 { margin: 0 0 4px; font-size: 16.5px; font-weight: 700; }
.module-card p { color: var(--muted); font-size: 13px; }
.module-card .cnt { margin-top: 12px; font-size: 12px; font-weight: 600; color: var(--accent2); }

/* 解读条目 */
.entry {
  background: var(--card); border: 1px solid var(--line); border-radius: var(--radius);
  padding: 18px 22px; margin: 14px 0; box-shadow: var(--shadow);
  transition: box-shadow .18s ease;
}
.entry:hover { box-shadow: var(--shadow-lift); }
.entry-head { display: flex; flex-wrap: wrap; align-items: baseline; gap: 10px; }
.entry-head h3 { font-size: 15px; font-family: ui-monospace, "SF Mono", Menlo, monospace; font-weight: 700; }
.entry-head .gene { color: var(--gold); font-weight: 700; font-size: 14px; }
.entry-head .variant { color: var(--muted); font-size: 12.5px; }
.gt-row { display: flex; flex-wrap: wrap; gap: 8px; margin: 10px 0; align-items: center; }
.gt-chip {
  font-family: "SF Mono", ui-monospace, Menlo, monospace;
  background: var(--grad); color: #fff;
  padding: 3px 14px; border-radius: 9px; font-size: 15px; font-weight: 700;
  box-shadow: 0 4px 10px -4px rgba(37, 99, 235, .45);
}
.gt-chip.dim { background: var(--bg2); color: var(--muted); box-shadow: none; border: 1px solid var(--line); }
.src-tag { font-size: 11.5px; color: var(--muted); }

/* 人话版 */
.plain {
  background: linear-gradient(90deg, #fffbeb, #fefce8);
  border: 1px solid #fde68a; border-radius: 12px;
  padding: 9px 14px; margin: 10px 0; font-size: 13.8px; color: #713f12;
}
.plain::before { content: "🗣️ 人话版："; font-weight: 700; color: #b45309; }

.resolved { border-left: 3px solid var(--line); padding: 4px 0 4px 14px; margin: 10px 0; }
.resolved .label { font-weight: 800; margin-bottom: 2px; font-size: 14.5px; }
.resolved.favorable { border-color: var(--green); }
.resolved.favorable .label { color: var(--green); }
.resolved.caution { border-color: var(--red); }
.resolved.caution .label { color: var(--red); }
.resolved.attention { border-color: var(--orange); }
.resolved.attention .label { color: var(--orange); }
.resolved.neutral .label { color: var(--accent2); }
.resolved p { font-size: 14px; color: #3d4a61; }
.entry-foot { display: flex; flex-wrap: wrap; gap: 10px; font-size: 12px; color: var(--muted); margin-top: 8px; align-items: center; }
.entry-foot a { color: var(--accent2); font-weight: 500; }
.conf { padding: 1px 10px; border-radius: 999px; border: 1px solid var(--line); background: var(--card2); }
.conf.high { color: var(--green); border-color: #bbf7d0; }
.conf.medium { color: var(--gold); border-color: #fde68a; }
.conf.low { color: var(--muted); }
.flag-note {
  color: var(--orange); font-size: 12.5px; margin: 8px 0;
  background: #fff7ed; border: 1px solid #fed7aa; border-radius: 10px; padding: 6px 12px;
}
.nc-note { color: var(--muted); font-size: 13px; font-style: italic; }
.cross-tag {
  font-size: 12px; color: var(--accent2); background: #eff6ff;
  border: 1px solid #bfdbfe; border-radius: 999px; padding: 2px 12px;
}

/* 特卡 */
.card-note {
  background: var(--card2); border: 1px solid var(--line); border-radius: var(--radius);
  padding: 16px 20px; margin: 12px 0; font-size: 14px; box-shadow: var(--shadow);
}
.card-note h4 { font-size: 14.5px; margin-bottom: 4px; font-weight: 700; }
.card-note.favorable { background: #f0fdf4; border-color: #bbf7d0; }
.card-note.favorable h4 { color: #15803d; }
.card-note.caution { background: #fef2f2; border-color: #fecaca; }
.card-note.caution h4 { color: #b91c1c; }
.card-note.attention { background: #fff7ed; border-color: #fed7aa; }
.card-note.attention h4 { color: #c2410c; }
.card-note p { color: #3d4a61; }

/* 表格 */
.tbl-wrap {
  overflow-x: auto; border: 1px solid var(--line); border-radius: var(--radius);
  margin: 16px 0; box-shadow: var(--shadow); background: var(--card);
}
table.tbl { width: 100%; border-collapse: collapse; font-size: 13px; min-width: 780px; }
.tbl th, .tbl td { padding: 9px 14px; border-bottom: 1px solid var(--line); text-align: left; white-space: nowrap; }
.tbl th { background: var(--bg2); color: var(--muted); font-weight: 700; position: sticky; top: 0; }
.tbl td .mono { font-family: ui-monospace, Menlo, monospace; }
.tbl tr:last-child td { border-bottom: none; }
.tbl tr:hover td { background: #f4f7fd; }
.tbl td a { font-size: 12px; margin-right: 8px; }

/* 染色体图 */
.chr-chart {
  background: var(--card); border: 1px solid var(--line); border-radius: var(--radius);
  padding: 22px 24px; margin: 16px 0; box-shadow: var(--shadow);
}
.bar-row { display: grid; grid-template-columns: 56px 1fr 100px; gap: 12px; align-items: center; margin: 5px 0; font-size: 12.5px; }
.bar-row .chr { font-weight: 700; font-family: ui-monospace, Menlo, monospace; }
.bar-track { background: var(--bg2); border-radius: 7px; height: 16px; overflow: hidden; display: flex; }
.bar-asa { background: var(--grad); height: 100%; border-radius: 7px 0 0 7px; }
.bar-imp { background: #bfdbfe; height: 100%; }
.bar-num { color: var(--muted); text-align: right; font-variant-numeric: tabular-nums; }

.kv-list { display: grid; grid-template-columns: repeat(auto-fit, minmax(250px, 1fr)); gap: 12px; margin: 16px 0; }
.kv { background: var(--card); border: 1px solid var(--line); border-radius: 14px; padding: 13px 16px; font-size: 13.5px; box-shadow: var(--shadow); }
.kv b { color: var(--accent2); display: block; font-size: 12px; font-weight: 700; }

/* 首页科普区 */
.popsci-hero { display: grid; grid-template-columns: repeat(auto-fit, minmax(240px, 1fr)); gap: 16px; margin: 16px 0; }
.popsci-hero .popsci-card { margin: 0; }
.popsci-hero .popsci-card .ic { font-size: 24px; display: block; margin-bottom: 6px; }

.site-footer { border-top: 1px solid var(--line); padding: 28px 0 44px; color: var(--muted); font-size: 12.5px; background: var(--card2); }
.site-footer p { margin: 3px 0; }

@media (max-width: 640px) {
  .brand h1 { font-size: 18px; }
  .hero { grid-template-columns: 1fr 1fr; }
  main { padding: 20px 16px 50px; }
}